diabet. Non-insulin-dependent diabetes mellitus
Conditions
Interventions
Intervention 1: Hesperidin, Capsules 500 mg, 1 time a day for 2 months. Intervention 2: Starch placebo capsules, 500 mg, 1 time a day for 2 months.
Treatment - Drugs
Placebo
Hesperidin, Capsules 500 mg, 1 time a day for 2 months
Starch placebo capsules, 500 mg, 1 time a day for 2 months
Sponsors
Iran University Medical Science
Eligibility
Sex/Gender
All
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Being volunteer or Wishing to attend 2.diagnosed with type 2 diabetes for at least 1 year (FPG = 126 mg/dl or 2hPG = 200 mg/dl)3. At least one year history of diabet 4. Not using tobacco 5. Lack of cardiovascular disease, liver disease, kidney disease, chronic inflammatory disease of the gastrointestinal tract 6.HbA1C < 8% 7. 20-65 y old 8. Lack of insulin 9. Not drinking alcohol 10. BMI<35 kg/m2 11. Not using any supplements, antioxidants and vitamins in the last 3 months 12. Not pregnant or nursing 13.TG<400 mg/dl 14. The absence of any skin allergies or digestive antioxidant supplements and vitamins. Exclusion criteria 1.The use of antioxidant supplements and vitamins 2.Use of insulin 3. See allergy symptoms at any time during the study 4.Taking over500ml beverages rich in flavonoids include tea, coffee, citrus juice, which it is determined by taking the 24-hour dietary recalls 5. Accept less than 70 6. Follow weight loss diets 7. NSAID nonsteroidal anti-inflammatory drugs and estrogens, oral contraceptives, anticonvulsants, corticosteroids
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| IL6. Timepoint: After the. Method of measurement: ELISA based on a scale pg / ml.;Hs CRP. Timepoint: After the intervention. Method of measurement: ELISA based on a scale ng / ml.;Glucose. Timepoint: Before the intervention and after the intervention. Method of measurement: Glucose oxidase method based on scale mg / dl.;Insulin. Timepoint: Before the intervention and after the intervention. Method of measurement: ELISA based on a scale µmol / ml.;Glycated hemoglobin. Timepoint: Before the intervention and after the intervention. Method of measurement: Chromatography based on the percentage of glycated hemoglobin.;TG. Timepoint: Before the intervention and after the intervention. Method of measurement: By an enzymatic method based on the scale mg / dl.;TC. Timepoint: Before the intervention and after the intervention. Method of measurement: By an enzymatic method based on the scale mg / dl.;LDL. Timepoint: Before the intervention and after the intervention. Method of measurement: To help Frydvald formula based on mg / dl.;HDL. Timepoint: Before the intervention and after the intervention. Method of measurement: By an enzymatic method based on the scale mg / dl.;Systolic blood pressure. Timepoint: Before the intervention and after the intervention. Method of measurement: Using a pressure gauge based on a scale mm Hg.;Diastolic blood pressure. Timepoint: Before the intervention and after the intervention. Method of measurement: Using a pressure gauge based on a scale mm Hg.;Insulin Resistance. Timepoint: Before the intervention and after the intervention. Method of measurement: Using the formula. | — |
Secondary
| Measure | Time frame |
|---|---|
| Age. Timepoint: Before the intervention and after the intervention. Method of measurement: Using Balance 0/1kg carefully based on kg scale.;BMI. Timepoint: Before the intervention and after the intervention. Method of measurement: Using the formula.;Physical activity. Timepoint: Before the intervention and after the intervention. Method of measurement: Using a questionnaire, based on three levels of light, medium and heavy.;Dietary intake. Timepoint: Before the intervention and after the intervention. Method of measurement: based on a 3-day recall measure kcal.;Gender. Timepoint: before the intervention. Method of measurement: Using view on men or women.;Types of drugs. Timepoint: Before the intervention and after the intervention. Method of measurement: Using a questionnaire based on observation.;Dose of drugs. Timepoint: Before the intervention and after the intervention. Method of measurement: Using a questionnaire based on the number of. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShahryar Eghtesadi
Iran University Medical School
Outcome results
None listed