The effect of Allopurinol on prevention of contrast-induced nephropathy

The effect of sodium chloride hydration with and without allopurinol on prevention of contrast-induced nephropathy in high risk patients undergoing coronary angiography

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014072318389N2

Enrollment

140

Registered

2014-09-24

Start date

2014-08-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute renal failure. Acute renal impairment

Interventions

Intervention 1: Interventional group: All patients will be received allopurinol (100mg, TDS) 24 h before administration of contrast agent plus intravenous hydration (1mg /kg/h Normal saline for 12 h p

Treatment - Drugs

Interventional group: All patients will be received allopurinol (100mg, TDS) 24 h before administration of contrast agent plus intravenous hydration (1mg /kg/h Normal saline for 12 h pre- and post-con

Control group: All patients will be received intravenous hydration (1 mL/kg/ h) Normal saline for 12 h pre- and post-contrast.

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients, who have at least one of the following risk factors: 1) Heart failure (25%75 years 4) Renal insufficiency (creatinine 1.5mg/dl) 5) Hypotension (SBP<80 mm Hg for 1 hour) 6) GFR<60/mL/min per 1.73 m2 7) Anemia 8) hypertension 9) Pulmonary edema Exclusion criteria: 1- Pregnancy and lactation 2- Allergy to radiographic contrast 3- Have cardiogenic shock and pulmonary edema during study 4- multiple myeloma, pulmonary ventilation and emergency catheterization 5- Serum creatinine levels< 4 mg/dL and preexisting dialysis 6- Exposure to contrast medium 48 h pre- and post-coronary angiography 7- Receive of diuretics, N-acetylcystein, sodium bicarbonate, Theophylline, Dopamine, Mannitol, Fenoldopam, Metformin and NSAID’S during the study 8- Needs to continuous hydration therapy (e.g., sepsis)

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Nephropathy. Timepoint: Before and 48 h after coronary angiography. Method of measurement: Serum creatinine, blood urea nitrogen (BUN), CRP and uric acid measurement.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactLeili Iranirad

Qom University of Medical Sciences and Health Services

lirani@muq.ac.ir+98 25 3612 2733

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026