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Evaluating effect of remifentanil in post-operative hyperalgesia and prophylactic effect of magnesium sulfate on it

Clinical trial of evaluating effect of remifentanil in post-operative hyperalgesia and prophylactic effect of magnesium sulfate

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT2014071216415N3
Enrollment
105
Registered
2014-08-02
Start date
2014-04-04
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypotension due to drugs. Hypotension due to drugs

Interventions

Intervention 1: Prescription of magnesium sulfate 30 mg/kg and continuous infusion of remifentanil 0.05 to 0.2 microgram/kg/min. Intervention 2: Prescription of placebo (normal saline) and continuous
Treatment - Drugs
Prescription of magnesium sulfate 30 mg/kg and continuous infusion of remifentanil 0.05 to 0.2 microgram/kg/min
Prescription of placebo (normal saline) and continuous infusion of remifentanil 0.05 to 0.2 microgram/kg/min
Prescription of placebo (normal saline) and continuous infusion of nitroglycerin 1 to 20 microgram/kg/min

Sponsors

Deputy of Research and technology of Isfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
15 Years to 65 Years

Inclusion criteria

Inclusion criteria: Age 15 to 65 years old; ASA 1 and 2; without history of usage of neuro-psychological drugs; without history of usage of NSAIDs; no contraindication for TNG; no contraindication for magnesium sulfate; no contraindication for remifentanil

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Severity of pain. Timepoint: Before discharge from recovery; 6 hours after surgery; 24 hours after surgery. Method of measurement: By VAS.—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactGolparvar M MD

Isfahan University of Medical Sciences

golparvar@med.mui.ac.ir+98 31 3624 9031

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026