Comparative study of the different treatment methods in size reduction of the benign thyroid nodules

Comparative study of Ethanol injection, Radiofrequency Ablation, and Levothyroxine Therapy in Patients with Benign Thyroid Nodules: A Multicenter Randomized clinical Trial in Iran

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20140712018457N6

Enrollment

Registered

2022-07-09

Start date

2021-10-07

Completion date

Unknown

Last updated

2022-08-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Benign thyroid nodule. Nontoxic single thyroid nodule

Interventions

Intervention 1: Intervention group: Patients treated with radiofrequency ablation and ethanol injection. Intervention 2: Control group: patients treated with Levothyroxine.

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Normal thyroid test including TSH, T?, T?, T?RU, Anti TPO The nodule has grown or the patient reports pressure sign FNA biopsy specimen or core needle biopsy under ultrasound guidance is benign. Normal blood calcitonin level The patient has not received previous treatment for thyroid nodules

Exclusion criteria

Exclusion criteria: Malignant sonographic features of thyroid nodules Malignant or non-diagnostic lesions in pathology results Pregnancy Abnormal thyroid function tests or abnormal calcitonin

Design outcomes

Primary

Measure	Time frame
Size of thyroid nodule. Timepoint: one, three and six month following related treatment. Method of measurement: Measurement of thyroid nodules size using ultrasound based on millimeters.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahsa Alborzi

Tehran University of Medical Sciences

mahsaalborzi94@gmail.com+98 21 6658 1579

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026