Hypertension. High Blood pressure
Conditions
Interventions
Intervention 1: The intervention group, Resveratrol ,99% pure(500 mg twice a day) for a period of one month. Intervention 2: The Control group, placebo ( 500 mg neutral cellulose, twice a day) for a p
Treatment - Drugs
Placebo
The intervention group, Resveratrol ,99% pure(500 mg twice a day) for a period of one month.
The Control group, placebo ( 500 mg neutral cellulose, twice a day) for a period of one month
Sponsors
Deputy of Research, Bushehr University of Medical Sciences
Eligibility
Sex/Gender
All
Age
30 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Pre-hypertensive(average of two times measurement with an interval of 15 minutes, diastolic and systolic blood pressure(80-89mmHg, 120-139 mmHg respectively) • Stage 1 hypertensive (average of two times measurement with an interval of 15 minutes (diastolic and systolic blood pressure 90-99 mmHg, 140-159 mmHg, respectively) • Male or Female • Age between 20 and 60-years • Ability to provide informed consent Exclusion Criteria:Approved or doubtful secondary hypertension; History of chronic or acute kidney Disease; History of heart failure; History of chronic or acute liver diseases; History of diabetes mellitus; History of prior cardiovascular events (Acute Myocardial Infarction, Cardiovascular diseases, Percutaneous Coronary Angioplasty or Coronary Artery Bypass Graft); Pregnancy or breast feeding;Blood arterial pressure >160/110
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diastolic and systolic blood pressure. Timepoint: once in a week during intervention period. Method of measurement: A sphygmomanometer and Stethoscope will be used to measure the blood pressure, once in a week, and average of two times within 15 minutes will be recorded.;Added at 2015-04-16: Mean arterial pressure. Timepoint: Added at 2015-04-16: once in a week during intervention. Method of measurement: Added at 2015-04-16: systolic blood BP plus 2 times diastolic BP divided by 3. | — |
Secondary
| Measure | Time frame |
|---|---|
| PTT. Timepoint: Before and after the first stage intervention, after one month washout and after one month of second stage intervention. Method of measurement: By Reputed kits.;SGOT. Timepoint: Before and after the first stage intervention, after one month washout and after one month of second stage intervention. Method of measurement: By Kits and ELISA method.;SGPT. Timepoint: Before and after the first stage intervention, after one month washout and after one month of second stage intervention. Method of measurement: By Kits and ELISA method.;GGT. Timepoint: Before and after the first stage intervention, after one month washout and after one month of second stage intervention. Method of measurement: By Kits and ELISA method.;ALP. Timepoint: Before and after the first stage intervention, after one month washout and after one month of second stage intervention. Method of measurement: By Kits and ELISA method.;TG. Timepoint: Before and after the first stage intervention, after one month washout and after one month of second stage intervention. Method of measurement: By Reputed kits.;Cholesterol. Timepoint: Before and after the first stage intervention, after one month washout and after one month of second stage intervention. Method of measurement: By Reputed kits.;LDL. Timepoint: Before and after the first stage intervention, after one month washout and after one month of second stage intervention. Method of measurement: By Reputed kits.;HDL. Timepoint: Before and after the first stage intervention, after one month washout and after one month of second stage intervention. Method of measurement: By Reputed kits.;Hematocrit. Timepoint: Before and after the first stage intervention, after one month washout and after one month of second stage intervention. Method of measurement: By Reputed kits.;Albumin. Timepoint: Before and after the first stage intervention, after one month washout and after one month of second stage intervention. Method of measurement: Auto-analyzer | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAli Movahed
Bushehr University of Medical Sciences
Outcome results
None listed