Improving the effectiveness of misoprostol cervical ripening with laminaria

Efficacy of sublingual misoprostol with sublingual misoprostol with laminaria on cervical dilation in the abortion rate from 4 to 14 weeks

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014070711020N4

Enrollment

Registered

2015-07-24

Start date

2015-07-24

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Abortion. termination of pregnancy: legal therapeutic therapeutic abortion

Interventions

Intervention 1: Intervention group:receive cervical laminaria plus 200µg sublingual misoprostol 4 hours before procedure. Intervention 2: procedure Control group: sublingual misoprostol 400µg 4 hours

Treatment - Other

Treatment - Drugs

Intervention group:receive cervical laminaria plus 200µg sublingual misoprostol 4 hours before procedure.

procedure Control group: sublingual misoprostol 400µg 4 hours befor procedure

Eligibility

Sex/Gender

Female

Age

18 Years to 35 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 18 to 35 years ;gestational age less than 14 weeks;closed cervix;ultrasound consecutive Blighted Ovoum or Missed Abortion or the termination of pregnancy to order a forensic document. Exclusion criteria: medical conditions such as diabetes or high blood pressure or heart disease; surgery on the cervical area of ??the convention; women who take certain medications or an underlying allergy;Women who have vaginal bleeding at presentation ; women with a BMI of less than 20 or more than 25 ; more than 2 previous cesarean section; uterine anomalies .

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
400µg sublingual misoprostol for cervical ripening. Timepoint: Every 4 hours. Method of measurement: =Hegar7.;Cervical ripening with:cervical laminaria plus 200µg sublingual misoprostol. Timepoint: Every 4 hours. Method of measurement: =Hegar7.	—

Secondary

Measure	Time frame
Symptoms of allergy to laminaria. Timepoint: every tow hours up to cervix prparation. Method of measurement: based on fever and Itching existance.;Fever. Timepoint: every 2 hours up to preparation ofcervix. Method of measurement: Medical thermometer.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Maryam Khooshide

Tehran University of Medical Sciences

khooshide@tums.ac.ir+90 217 788 32 88

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Mar 13, 2026