Evaluation effect intrauterine administration of peripheral blood lymphocyte cells on expression of endometrial estrogen and progesterone receptor

Evaluation effect intrauterine administration of peripheral blood lymphocyte cells on expression of endometrial estrogen and progesterone receptor on implantation window in women with repeated implantation failure

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20140707018381N3

Enrollment

Registered

2018-07-30

Start date

2018-01-06

Completion date

Unknown

Last updated

2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility. Female infertility, unspecified

Interventions

Intervention 1: Intervention group: A group of patients are in lymphocyte therapy group. Five days before endometrial biopsy, 5 cc blood samples were taken and their peripheral blood lymphocytes were

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: At least =3 previous implantation failure in IVF or ICSI cycles No history of clinical pregnancy (primary infertility) not receiving any steroidal hormone = 2 months were entered in this study

Exclusion criteria

Exclusion criteria: genetic disorders history of repeated infectious diseases Endometriosis uterine anatomic abnormalities

Design outcomes

Primary

Measure	Time frame
The mRNA levels of both estrogen receptors and progesterone receptors in endometrial tissues. Timepoint: at the implantation window time, during the mid-secretory phase (LH+7 days) of each menstrual cycle. Method of measurement: The sample of tissue is analyzed using the quantitative real-time polymerase chain reaction (qRT-PCR) technique.	—

Secondary

Measure	Time frame
The protein expression estrogen receptors and progesterone receptors in endometrial tissues. Timepoint: at the implantation window time, during the mid-secretory phase (LH+7 days) of each menstrual cycle. Method of measurement: immunohistochemical staining.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Fattaneh Farifteh

Shahid Beheshti University of Medical Sciences

f.farifteh@gmail.com+98 21 2243 9956

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026