Comparison effect intrauterine administration of peripheral blood lymphocyte cells on pregnancy outcome on patients with repeated implantation failur

Comparison effect intrauterine administration of peripheral blood lymphocyte cells on pregnancy outcome on patients with repeated implantation failure on fresh embryo transfer cycles and frozen/thawed embryo transfer cycles

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20140707018381N2

Enrollment

160

Registered

2017-12-03

Start date

2016-03-19

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility. Female infertility, unspecified

Interventions

Intervention 1: 1. A group of patients undergoing lymphocyte therapy in the fresh embryo transfer cycle. in these patients, 5 cc blood samples were taken in one day before day of HCG injection, and th

Treatment - Drugs

1. A group of patients undergoing lymphocyte therapy in the fresh embryo transfer cycle. in these patients, 5 cc blood samples were taken in one day before day of HCG injection, and then their periphe

2-Another group of patients are in the frozen/thawed embryo transfer lymphocyte therapy cycle. Five days before embryo transfer, 5 cc blood samples were taken and their peripheral blood lymphocytes we

3. The control group haven’t any blood samplings and lymphocyte injection into the uterus

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: at least =3 previous implantation failure in IVF or ICSI cycles No history of clinical pregnancy (primary infertility) No poor ovarian reserve (FSH <15 mIU/ml) Endometrial thickness 7< in ovulation induction time BMI < 30

Exclusion criteria

Exclusion criteria: Women with history of repeated infectious diseases in the past; Endometriosis Uterine pathology such as uterine lymphomas The known etiology of recurrent implantation failure as chromosomal disorders were excluded from the study

Design outcomes

Primary

Measure	Time frame
Multiple pregnancy rate. Timepoint: 14 weeks of pregnancy. Method of measurement: sonography.;Abortion rate. Timepoint: 20 weeks after pregnancy. Method of measurement: sonography.	—

Secondary

Measure	Time frame
Clinical pregnancy rate. Timepoint: after intervention. Method of measurement: sonography.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFattaneh Farifteh

Shahid Beheshti University of Medical Sciences

f.farifteh@gmail.com+98 21 2243 9956

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026