Reduction or prevention of Myoclonus after Etomidate infusion

The comparison of the effect of pretreatment with low dose of midazolam, low dose of etomidate, remifentanyl and sulfate magnesium on reduction or prevention of myoclonus after etomidate induction in orthopedic surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014070613456N1

Enrollment

284

Registered

2014-08-14

Start date

2014-08-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myoclonus. Drug-induced myoclonus

Interventions

Intervention 1: Intervention1: Injection of low dose of Midazolam 0.015mg/kg as a premed before Etomidate. Intervention 2: Intervention 2: Injection of sulfate magnesium 30 mg/kg before induction of

Prevention

Intervention1: Injection of low dose of Midazolam 0.015mg/kg as a premed before Etomidate

Intervention 2: Injection of sulfate magnesium 30 mg/kg before induction of anesthesia with Etomidate

Intervention 3: Injection of Remifentanyl 1 micg/kg before Etomidate

Intervention 4: Injection of low dose of Etomidate 0.03 mg/kg before induction of anesthesia with Etomidate

Eligibility

Sex/Gender

All

Age

18 Years to 59 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: ASA ( American Society of Anesthesiologists) I, II; age between 18 to 59 years old. Exclusion criteria: patients with Neurological problems; allergy; those who have received sedative or analgesic drugs in the 24 hours ago.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Myoclonus. Timepoint: Within 90 seconds after injection of Etomidate as the main drug for induction of anesthesia. Method of measurement: Myoclonus Grade.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAbbas Sedighinejad

Guilan University of Medical Sciences

arcguilan1392@gums.ac.ir;a_sedighinejad@gums.ac.ir+98 13 1322 3960

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026