Facial Wrinkles. Changes in skin texture
Conditions
Interventions
Intervention 1: Intervention group: In this group, one side of the participants' face (based on randomization) was treated with microneedling with secretome extracted from placental mesenchymal stem c
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
30 Years to 59 Years
Inclusion criteria
Inclusion criteria: Women aged 30-59 Have not had facial Botox injections within 6 months prior to study entry Have not had facial filler injections within 1 year prior to study entry Have evidence of skin aging including superficial wrinkles
Exclusion criteria
Exclusion criteria: Patients with severe dermatitis or psoriasis or any other Koebner-positive disease. Acne, herpes, or autoimmune diseases History of cancer or chemotherapy Pregnancy or breastfeeding Taking certain medications, including corticosteroids or immunosuppressants Presence of coagulation problems Evidence of keloids or scars or difficulty in wound healing
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of skin wrinkles. Timepoint: Before the intervention, four weeks after the first session, eight weeks after the first session, and twelve weeks after the first session. Method of measurement: Visual analog scale and clinical assessment.;Patient satisfaction. Timepoint: Before the intervention began, four weeks after the first session, eight weeks after the first session, and twelve weeks after the first session. Method of measurement: Visual analog scale.;Treatment side effects. Timepoint: Before the intervention began, four weeks after the first session, eight weeks after the first session, and twelve weeks after the first session. Method of measurement: Clinical assessment. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohamad Reza Ranjkesh
Tabriz University of Medical Sciences
Outcome results
None listed