The effect of exosomes with hydroquinone in the treatment of resistant facial melasma

The effect of exosomes extracted from mesenchymal stem cells derived from adipose tissue with hydroquinone in the treatment of resistant facial melasma

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20140705018373N8

Enrollment

Registered

2025-06-10

Start date

2025-06-22

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Melasma. Chloasma

Interventions

Intervention 1: Intervention group 1 or control group: 10 patients will receive 4% hydroquinone topically on both sides of the face, at night before bed, for six months. Intervention 2: Intervention g

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients with bilateral melasma on the face Age above 18 years and below 60 years History of using topical medications for melasma in the past 6 months without adequate treatment response Consent to participate in the study

Exclusion criteria

Exclusion criteria: Not consenting to participate in the study Pregnancy or breastfeeding Concurrent use of other melasma treatments including laser therapy

Design outcomes

Primary

Measure	Time frame
Response to treatment. Timepoint: Months 1, 2, 4, 6. Method of measurement: MASI score.;Treatment side effects. Timepoint: Months 1, 2, 4, 6. Method of measurement: Clinical evaluation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mohammadreza Ranjkesh

Tabriz University of Medical Sciences

ranjkeshm@tbzmed.ac.ir+98 41 3549 8236

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026