Effect of both PRP and 15% AHA versus 15% AHA alone on facial wrinkles

Comparison of the therapeutic response of both PRP and 15% AHA versus 15% AHA alone in patients with facial wrinkles

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20140705018373N5

Enrollment

Registered

2020-11-11

Start date

2020-09-22

Completion date

Unknown

Last updated

2020-11-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Facial wrinkles.

Interventions

Intervention 1: Intervention group: Patients will receive 15% alpha-hydroxy acid overnight topically with platelet-rich plasma injection every two months for 6 months. Intervention 2: Control group: P

Eligibility

Sex/Gender

All

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Age between 18 to 45 years Satisfaction to participate in the study

Exclusion criteria

Exclusion criteria: Platelet disorder or blood clots Chronic liver disease Autoimmune diseases History of drug treatment with bleeding or clotting mechanisms, Having cosmetic treatments in the past 6 months Pregnancy

Design outcomes

Primary

Measure	Time frame
Facial wrinkles severity. Timepoint: Initiation of the study, 1, 3 and 6 months after the intervention. Method of measurement: Wrinkle Severity Rating Scale.;Degree of tissue healing and homogeneity of facial skin. Timepoint: Initiation of the study, 1, 3 and 6 months after the intervention. Method of measurement: Skin Homogeneity and Texture Scale.;Patient satisfaction. Timepoint: 6 months after the intervention. Method of measurement: Asking from patients on a scale of 1 to 5 range from very dissatisfied to very satisfied.	—

Measure

Time frame

Facial wrinkles severity. Timepoint: Initiation of the study, 1, 3 and 6 months after the intervention. Method of measurement: Wrinkle Severity Rating Scale.;Degree of tissue healing and homogeneity of facial skin. Timepoint: Initiation of the study, 1, 3 and 6 months after the intervention. Method of measurement: Skin Homogeneity and Texture Scale.;Patient satisfaction. Timepoint: 6 months after the intervention. Method of measurement: Asking from patients on a scale of 1 to 5 range from very dissatisfied to very satisfied.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mohammadreza Ranjkesh

Tabriz University of Medical Sciences

ranjkeshm@tbzmed.ac.ir+98 41 3549 8236

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026