Investigation the effectiveness of intravenous levetiracetam for acute neonatal seizures control

A Comparison Evaluation of the Efficiency of Levetiracetam and intravenous phenobarbital for Treatment of Acute Neonatal Seizures

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20140703018334N2

Enrollment

Registered

2018-08-05

Start date

2015-08-23

Completion date

Unknown

Last updated

2018-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neonatal seizure. Convulsions of newborn

Interventions

Intervention 1: In the intervention group, levetiracetam is used to treat neonatal seizures with the initial loading dose of 40mg/kg, which is a slow intravenous infusion in 15 minutes diluted with no

Eligibility

Sex/Gender

All

Age

1 Days to 28 Days

Inclusion criteria

Inclusion criteria: Neonatal seizures are diagnosed according to history and clinical symptoms Neonates with seizure based on pediatric neurologist confirmation and EEG interpretation

Exclusion criteria

Exclusion criteria: Seizure due to metabolic causes Seizures due to electrolyte causes

Design outcomes

Primary

Measure	Time frame
Seizure control. Timepoint: 5 minutes after drug injection. Method of measurement: EEG and clinical symptoms.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMostafa Sedighi

Kermanshah University of Medical Sciences

m.sedighi@kums.ac.ir+98 83 1721 8204

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026