Prophylactic antibiotic in ventilator associated pneumonia

Prophylactic antibiotic for Early Ventilator associated Pneumonia in stroke Patients

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201407029855N6

Enrollment

Registered

2014-07-21

Start date

2014-03-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ventilator Associated Pneumonia. Pneumonia, unspecified

Interventions

Intervention 1: Patients in the case group receive intravenous piperacillin - tazobactam 4.5 g (piperacillin 4 g and tazobactam 0.5 g) simultaneously with intubation and then 12 hours after intubation

Prevention

Patients in the case group receive intravenous piperacillin - tazobactam 4.5 g (piperacillin 4 g and tazobactam 0.5 g) simultaneously with intubation and then 12 hours after intubation and simultaneou

Patients in the control group receive intravenous normal saline simultaneously with intubation and then 12 hours after intubation and simultaneously receive subsequent treatment that was similar in bo

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: age over 20 years; Glasgow scale of less than 9, less than 12 hours of mechanical ventilation passed; at least 48 hours under of mechanical ventilation. Exclusion criteria: patients who admitted 48 hours before intubation in hospital; patients who received more than two doses of antibiotics before intubation; Patients who have need antibiotics for any reason; patients who are candidates for organ donation; patients with immunodeficiency; patients who are allergic to piperacillin-tazobactam.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Early ventilator associated pneumonia. Timepoint: Days 1,2,3,4. Method of measurement: Chest X ray, clinical signs, microbiological study.	—

Secondary

Measure	Time frame
Late ventilator associated pneumonia. Timepoint: Days 5 , 7, 10 , 14. Method of measurement: Chest X ray, clinical sign and Microbiology study.;Mortality report. Timepoint: Daily to two weeks. Method of measurement: Reviewing date of death.;Length of stay in ICU. Timepoint: Daily to two weeks. Method of measurement: Reviewing date of discharge.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. aliasghar Farazi

Arak University of Medical Sciences

farazialiasghar@yahoo.com+98 86 3224 1411

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026