primary hypothyroidism. Hypothyroidism, unspecified
Conditions
Interventions
Intervention 1: Oral levothyroxine 1.6 mcgr per kg before sleep for 8 weeks. Intervention 2: Oral levothyroxine 1.6 mcgr per kg half an hour before breakfast for 8 weeks.
Treatment - Drugs
Oral levothyroxine 1.6 mcgr per kg before sleep for 8 weeks
Oral levothyroxine 1.6 mcgr per kg half an hour before breakfast for 8 weeks
Sponsors
Vice-chancellor for Research the Technology, Hamadan University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria: (a) patients with primary hypothyroiditis; (b) age of 18 years or older. Exclusion criteria: (a) history of cardiovascular disease; (b) being pregnant or plan to pregnant; (c) history of malabsorption or gastritis; (d) using drug reducing levothyroxine absorption such as aluminum or sucralfate.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Response to treatment. Timepoint: 8 months after treatment. Method of measurement: based on serum T4 level.;Response to treatment. Timepoint: 8 months after treatment. Method of measurement: based on serum TSH level. | — |
Secondary
| Measure | Time frame |
|---|---|
| Probable systematic adverse effects such as nausea and vomiting. Timepoint: 8 months after treatment. Method of measurement: through history taking. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Bahareh Babeway
Farshchian Hospital
Outcome results
None listed