Brucellosis. Brucellosis
Conditions
Interventions
Intervention 1: oral hydroxychloroquine 400 mg daily for two months plus standard drug therapy for brucellosis. Intervention 2: only standard drug therapy for brucellosis.
Treatment - Drugs
oral hydroxychloroquine 400 mg daily for two months plus standard drug therapy for brucellosis
only standard drug therapy for brucellosis
Sponsors
Vice-chancellor for Research the Technology, Hamadan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: (a) patients with sign and symptoms of brucellosis have Wright test of more than 1/160 and 2ME titer more than 1/80; (b) patients with chronic brucellosis who did not responded to standard drug therapy with constant or increased 2ME titer; (c) age of 18 years or older. Exclusion criteria: (a) being pregnant; (b) having history of porphyria, psoriasis, degenerative macula, hemolytic diseases, gastrointestinal diseases, neurologic diseases, and G6PD deficiency.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Response to treatment. Timepoint: before treatment and 1, 2, 3, and 5 months later. Method of measurement: based on 2ME titer. | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of probable adverse effects such as hepatitis and visual impairment. Timepoint: at 1, 2, 3, and 5 months after treatment. Method of measurement: through history taking and physical examination. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Mohammad Mahdi Majzoobi
Farshchian Hospital
Outcome results
None listed