myocardial infarction. Acute transmural myocardial infarction of unspecified site
Conditions
Interventions
Intervention 1: Intervention 1: patients will receive four oral Allopurinol 100mg tablets when arriving at the emergency department, followed by one 100mg tablet daily for 4 weeks.
Allopurinol is a x
Treatment - Drugs
Intervention 1: patients will receive four oral Allopurinol 100mg tablets when arriving at the emergency department, followed by one 100mg tablet daily for 4 weeks.
Allopurinol is a xanthine oxidase
Intervention 2: Placebo tablets are similar in appearance with Allopurinol tablets,which patients will receive four oral tablets when arriving at the emergency department, followed by one tablet daily
Sponsors
Vice chancellor for research,, Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Patients with first acute STEMI who are candidates for fibrinolytic therapy Exclusion criteria: Patients with firs acute STEMI who are candidates for Primary PCI, Patients with previous myocardial infarction or Primary valvular disease
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ST resolution (in milimeter). Timepoint: On arriving at the emergency department (before the intervention) and 90 minute after streptokinase adminsteration(intervention) in emergency department. Method of measurement: ECG. | — |
Secondary
| Measure | Time frame |
|---|---|
| Cardiac biomarkers level. Timepoint: first 48 hour (arrival at the emergency department (before the intervention) and then daily(after the intervention)). Method of measurement: laboratory.;Heart failure. Timepoint: During hospitalization. Method of measurement: Physical examination and history and echocardiography.;Recurrent myocardial infarction. Timepoint: six month after intrvention (streptokinase). Method of measurement: Telephone follow-up and patients hospital records.;In hospital death. Timepoint: During hospitalization. Method of measurement: Physical examination.;Six month death. Timepoint: six month after intrvention (streptokinase). Method of measurement: Telephone follow-up and patients hospital records.;Re-hospitalization for acute decompensation of heart failure. Timepoint: six month after intrvention (streptokinase). Method of measurement: Telephone follow-up and patients hospital records.;Repeat revascularization. Timepoint: six month after intrvention (streptokinase). Method of measurement: Telephone follow-up and patients hospital records. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSamad Ghaffari
Cardiovascular Research Center
Outcome results
None listed