Condition 1: pneumonia. Condition 2: Bacteremia. Diseases of the respiratory system Bacterial positive blood culture
Conditions
Interventions
Intervention 1: Control: Colistin 9 million international unit daily administered as 3 million international unit three times daily. Intervention 2: Intervention: Colistin 9 million international unit
Treatment - Drugs
Control: Colistin 9 million international unit daily administered as 3 million international unit three times daily
Intervention: Colistin 9 million international unit daily administered as 9 million international unit once daily
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 139 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Adult patients with positive blood or sputum culture. Exclusion criteria: Age 35 Kg/m2; Alanine Aminotransferase Or Aspartate Aminotransferase Level >8-fold The Upper Limit Of Normal; Bilirubin >4 mg/dl;Creatinine Clearance (Crcl) (Determined With The Cockcroft- Gault Formula) <40 ml/min, Colistin IT or Nebulization administration, Colistin treatment for <72 hours
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficacy of treatment regimen in infection control. Timepoint: Entrance to study,3,5 and 7 days after intervention. Method of measurement: patient culture, vital signs and procalcitonin. | — |
Secondary
| Measure | Time frame |
|---|---|
| Nephrotoxicity of treatment regimens. Timepoint: Daily. Method of measurement: RIFLE criteria. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Sistanizad
Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences
Outcome results
None listed