Ketamine efficacy on succinylcholine induced myalgia in outpatient surgeries

Comparison the effect of Ketamin and placebo on succinylcholine induced Myalgia in candidates of outpatient surgeries - A Double Blind Randomized Controlled Trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014062412789N5

Enrollment

144

Registered

2014-09-13

Start date

2013-11-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myalgia. Myalgia

Interventions

Intervention 1: ketamine 0.5 Mg per Kg (By adding distilled water the volume was reached to 5 mm) was injected to patients in the intervention group. Then 1.5 mic per kg fentanyl was injected as pre-

Treatment - Drugs

Placebo

ketamine 0.5 Mg per Kg (By adding distilled water the volume was reached to 5 mm) was injected to patients in the intervention group. Then 1.5 mic per kg fentanyl was injected as pre-medication prior

In the intervention group 5 mm distilled water was injected. Then 1.5 mic per kg fentanyl was injected as pre-medication prior to induction of anesthesia and 3 minutes after administration of ketamine

Eligibility

Sex/Gender

All

Age

15 Years to 75 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: candidates for elective outpatient surgery, physical condition in accordance with classes I and II of American Society of Anesthesiologists Classification Exclusion criteria: history of allergy to drugs, a history of malignant hyperthermia, history of neuromuscular disease (myopathy)

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Hemodynamic changes. Timepoint: Before induction of anesthesia, immediately before intubation and 5 minutes after intubation. Method of measurement: Heart rate and blood pressure that measured by machine would be read on monitor and recorded in check list. After complete relaxation, intubation is performed and again after 5 minutes, blood pressure and heart rate would measure and recorded in check list.;Myalgia. Timepoint: 24 hours after surgery. Method of measurement: 4-point scale: nil = no muscle pains or stiffness; mild = muscle pains or stiffness at one site but not causing disability or limiting activities; moderate = muscle pains or stiffness at more than one site but not causing disability or limiting activities; severe = muscle pains or stiffness at one site or more and causing disability or limiting activities, e.g., difficulty getting out of bed or turning the head.	—

Measure

Time frame

Hemodynamic changes. Timepoint: Before induction of anesthesia, immediately before intubation and 5 minutes after intubation. Method of measurement: Heart rate and blood pressure that measured by machine would be read on monitor and recorded in check list. After complete relaxation, intubation is performed and again after 5 minutes, blood pressure and heart rate would measure and recorded in check list.;Myalgia. Timepoint: 24 hours after surgery. Method of measurement: 4-point scale: nil = no muscle pains or stiffness; mild = muscle pains or stiffness at one site but not causing disability or limiting activities; moderate = muscle pains or stiffness at more than one site but not causing disability or limiting activities; severe = muscle pains or stiffness at one site or more and causing disability or limiting activities, e.g., difficulty getting out of bed or turning the head.

—

Secondary

Measure	Time frame
Complications. Timepoint: During the surgery and in recovery room. Method of measurement: Observation and monitoring the patient in the recovery room by the researcher.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSanaz Arvin

Kurdistan University of Medical Sciences

sanazarvin66@gmail.com+98 87 3328 5910

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026