Evaluating the efficacy of Metformin with Isotretinoin in the treatment of acne

Evaluating the efficacy of Metformin with Isotretinoin in the treatment of patient with acne or delayed acne

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20140624018210N8

Enrollment

Registered

2018-10-21

Start date

2018-05-04

Completion date

Unknown

Last updated

2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acne. Acne

Interventions

Intervention 1: Intervention group: Metformin with a dose of 500 mg twice a day for 6 months will be taken along with other prescribed medicines. Intervention 2: Control group: Oral isotretinoin will

Eligibility

Sex/Gender

All

Age

25 Years to 50 Years

Inclusion criteria

Inclusion criteria: Start acne from adolescence and continue acne until the age of 25 Start acne from adolescence and continue after 25 years Start acne after 25 years

Exclusion criteria

Exclusion criteria: History of taking Metformin or Isotretinoin History of chronic diseases of kidney, liver or heart

Design outcomes

Primary

Measure	Time frame
Changes of acne severity. Timepoint: 1, 3 and 6 months after intervention. Method of measurement: Clinical examination.	—

Secondary

Measure	Time frame
Fasting blood sugar. Timepoint: Before starting the intervention and 6 months after the intervention. Method of measurement: Blood test.;Cholesterol. Timepoint: Before starting the intervention and 6 months after the intervention. Method of measurement: Blood test.;Triglyceride. Timepoint: Before starting the intervention and 6 months after the intervention. Method of measurement: Blood test.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactElham Behrangi

Iran University of Medical Sciences

behrangi.e@iums.ac.ir+98 21 6435 2421

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026