Ulcerative Colitis. Ulcerative colitis
Conditions
Interventions
Intervention 1: 1 ml 300000 Iu vitamin D3 injection. Intervention 2: 1 ml normal saline.
Treatment - Drugs
Placebo
1 ml 300000 Iu vitamin D3 injection
1 ml normal saline
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Ulcerative Colitis patients according to examinations, Colonoscopy, biopsy and medical history endorsed by specialized physician; Remission phase (mild and moderate, not active); Voluntary attendance; Age between 18 to 50 years; Body mass index between 18.5 to 30 kg/m2 Exclusion criteria: Relapse phase patients; Pregnant and lactating women; Patients who receive Anti-TNF-alpha drugs like Infliximab and patients who take Cyclosporine; Patints who have received any form of vitamin D 3 months before intervention
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum level Tumor Necrosis Factor alpha (TNF-a). Timepoint: Before an 3 months after intervention. Method of measurement: ELISA kit.;Serum level of Asymmetric dimethylarginine (ADMA). Timepoint: Before an 3 months after intervention. Method of measurement: ELISA kit.;Serum level of Interferon gamma (IFN-?). Timepoint: Before an 3 months after intervention. Method of measurement: ELISA kit.;Serum level of Interleukin 4 (IL-4). Timepoint: Before an 3 months after intervention. Method of measurement: ELISA kit.;Serum level of Interleukin 10 (IL-10). Timepoint: Before an 3 months after intervention. Method of measurement: ELISA kit.;Serum level of Interleukin 12 (IL-12). Timepoint: Before an 3 months after intervention. Method of measurement: ELISA kit.;Serum level hs-CRP. Timepoint: Before an 3 months after intervention. Method of measurement: ELISA kit.;Cathelicidin (LL-37) gene expression. Timepoint: Before an 3 months after intervention. Method of measurement: qRT-PCR.;Added at 2017-04-15: CD40L (CD154) gene expression (Fold change). Timepoint: Added at 2017-04-15: 3 months after the intervention. Method of measurement: Added at 2017-04-15: qRT-PCR. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum Total Calcium. Timepoint: Before and 3 months after intervention. Method of measurement: Calcium Arsenazo III Reagent.;Dietary intake of Energy, Charbohydrate, Protein and Fat. Timepoint: Before and 3 months after intervention. Method of measurement: Three days 24-hour food recall.;Body Mass Index. Timepoint: Before and 3 months after intervention. Method of measurement: ?Scale; Stadiometer; calculation.;Body temperature. Timepoint: Before and 3 months after intervention. Method of measurement: Thermometer.;Hemoglobin. Timepoint: Before and 3 months after intervention. Method of measurement: Photometric detection of cyanmetahemoglobin.;Serum Level of 25-Hydroxy Vitamin D3. Timepoint: Before and 3 months after intervention. Method of measurement: Elisa kit.;Serum level of Parathyroid Hormone (PTH). Timepoint: Before and 3 months after intervention. Method of measurement: Elisa kit.;Systolic and diastolic blood pressure. Timepoint: Before and 3 months after intervention. Method of measurement: Sphygmomanometer.;Beck Depression score. Timepoint: Before and 3 months after intervention. Method of measurement: Beck Depression Inventory. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAmrollah Sharifi
Golestan University of Medical Sciences
Outcome results
None listed