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Effect of Addition of Clonidine to Bupivacaine in Spinal Anesthesia on Analgesia after Cruciate Ligament Repair

Effect of Addition of Clonidine to Bupivacaine in Spinal Anesthesia on Analgesia and Hemodynamic after Cruciate Ligament Repair: A Randomized Double Blinded Clinical Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT2014062117413N5
Enrollment
50
Registered
2014-06-29
Start date
2013-07-11
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sprain and strain involving (anterior)(posterior) cruciate ligament of knee. injury of cruciate ligament of knee

Interventions

Intervention 1: Second group received 15 mg 0.5% bupivacaine plus 75 µg clonidine with a total volume of 0.5 ml intrathecally. Intervention 2: The first group received 0.5% bupivacaine with a total do
Treatment - Drugs
Second group received 15 mg 0.5% bupivacaine plus 75 µg clonidine with a total volume of 0.5 ml intrathecally.
The first group received 0.5% bupivacaine with a total dose of 15 mg plus 0.5 ml saline solution intrathecally.

Sponsors

Baqiyatallah University of Medical Sciences, Deputy of Research
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients candidate ACL reconstruction surgery under spinal anesthesia at Baqiyatallah Hospital; Age over 18. Exclusion criteria: history of chronic pain; multiple trauma; long-term consumption of opioids and analgesics; history of alcohol consumption; absolute or partial contraindication of spinal injections; allergy to clonidine and bupivacaine.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Two Sensory Dermatome Regression Time. Timepoint: After operation. Method of measurement: Minute.;Motor Regression time. Timepoint: After operation. Method of measurement: Minute.;Post operative pain severity. Timepoint: at the time of needing analgesia. Method of measurement: visual analogue score (0-10).;Time of needing analgesia. Timepoint: After operation. Method of measurement: Minute.

Secondary

MeasureTime frame
Voiding time. Timepoint: After operation. Method of measurement: Minute.;Blood pressure. Timepoint: After operation. Method of measurement: mmHg.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHamidreza Karimi Sari

Students’ Research Committee (SRC), Baqiyatallah University of Medical Sciences, Tehran, IR Iran

dr.karimih@yahoo.com+98 21 8126 4354

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026