comparision of single dose amitriptiline versus pregabalin on postoperative pain reduction after spinal surgery

Effect of of single dose amitriptiline versus pregabalin on postoperative pain reduction in patients after spinal surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201406151617N9

Enrollment

Registered

2015-10-04

Start date

2014-03-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Low back pain. Radiculopathy

Interventions

Intervention 1: amitriptyline 25 mg oral tablet with a glass of water 30 minutes before induction of anesthesia. Intervention 2: Pregabalin 300 mg oral tablet with a glass of water 30 minutes before i

Prevention

amitriptyline 25 mg oral tablet with a glass of water 30 minutes before induction of anesthesia

Pregabalin 300 mg oral tablet with a glass of water 30 minutes before induction of anesthesia

Placebo oral tablet with a glass of water 30 minutes before induction of anesthesia

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: candidate for elective spinal surgery; lack of severe systemic and mental disease; consent to participate in the study Exclusion criteria: history of drug allergy; opiate use; sedative use

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: 0,1,4,6 hours after surgery. Method of measurement: Visual analogue score.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactTayebeh Khademi

Kermanshah University of Medical Sciences

mchoobsaz@kums.ac.ir+98 83 1724 6708

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026