the preemptive effect of Dexmedetomidine and ketorolac on post operative pain of appendectomy

Comparison of the preemptive effect of Dexmedetomidine and ketorolac on post operative pain of appendectomy

Status

Active, not recruiting

Phases

Phase 2

Study type

Observational

Source

IRCT

Registry ID

IRCT20140615018091N9

Enrollment

Registered

2019-01-10

Start date

2018-08-03

Completion date

Unknown

Last updated

2019-01-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

post operative pain of appendectomy.

Interventions

Intervention 1: The first intervention group received intravenous dexmedetomidine( Precedex (dexmedetomidine hydrochloride) Hospira, Inc. Lake Forest, IL 60045 USA) 1 µg / kg as bolus dose within 10 m

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Appendicitis patients with ASA classification 1 & 2 18-65 years old

Exclusion criteria

Exclusion criteria: History of allergy to any of the drugs used in the study Patient with ASA classification above two Addicted patients Neuropathy or misuse of pain medication Treatment with analgesics or anti-inflammatory drugs Pregnancy and lactation Patients with complicated appendectomy

Design outcomes

Primary

Measure	Time frame
Vas score. Timepoint: at 1, 3, 6, 12 and 24 hours after operation. Method of measurement: Visual Analogue Scale (VAS).	—

Secondary

Measure	Time frame
PCA use. Timepoint: at 24 hours after operation. Method of measurement: ml.;Age. Timepoint: Before entering the study. Method of measurement: ID card.;Weight. Timepoint: After entering the study and obtaining consent. Method of measurement: kg.;Blood pressure. Timepoint: before intubation, immediately after intubation, at 5, 10, 15, 20, 30, 40 and every 10 minutes till the end of operation. Method of measurement: monitoring - mmHg.;Heart rate. Timepoint: before intubation, immediately after intubation, at 5, 10, 15, 20, 30, 40 and every 10 minutes till the end of operation. Method of measurement: monitoring - Number per minute.;Body temperature. Timepoint: before intubation, immediately after intubation, at 5, 10, 15, 20, 30, 40 and every 10 minutes till the end of operation. Method of measurement: Thermometer - C.;SpO2. Timepoint: before intubation, immediately after intubation, at 5, 10, 15, 20, 30, 40 and every 10 minutes till the end of operation. Method of measurement: Pulse Oxymetry.;Nausea – vomiting. Timepoint: In recovery and 24 hours after surgery. Method of measurement: questionnaire.;Shivering. Timepoint: In recovery and 24 hours after surgery. Method of measurement: questionnaire.	—

Measure

Time frame

PCA use. Timepoint: at 24 hours after operation. Method of measurement: ml.;Age. Timepoint: Before entering the study. Method of measurement: ID card.;Weight. Timepoint: After entering the study and obtaining consent. Method of measurement: kg.;Blood pressure. Timepoint: before intubation, immediately after intubation, at 5, 10, 15, 20, 30, 40 and every 10 minutes till the end of operation. Method of measurement: monitoring - mmHg.;Heart rate. Timepoint: before intubation, immediately after intubation, at 5, 10, 15, 20, 30, 40 and every 10 minutes till the end of operation. Method of measurement: monitoring - Number per minute.;Body temperature. Timepoint: before intubation, immediately after intubation, at 5, 10, 15, 20, 30, 40 and every 10 minutes till the end of operation. Method of measurement: Thermometer - C.;SpO2. Timepoint: before intubation, immediately after intubation, at 5, 10, 15, 20, 30, 40 and every 10 minutes till the end of operation. Method of measurement: Pulse Oxymetry.;Nausea – vomiting. Timepoint: In recovery and 24 hours after surgery. Method of measurement: questionnaire.;Shivering. Timepoint: In recovery and 24 hours after surgery. Method of measurement: questionnaire.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFereydoon Fekrat

Bandare-abbas University of Medical Sciences

fereydoonfekrat@yahoo.com+98 76 3334 5009

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026