acute acetaminophen poisoning. Intentional self-poisoning by and exposure to nonopioid analgesics, antipyretics and antirheumatics
Conditions
Interventions
In all patient who were history of acute acetaminophen poisoning with toxic dose (>7.5gram), immediately administered N - acetylcysteine as the standard dose. All the subjects received 218.75 mg/ kg N
Treatment - Drugs
Sponsors
Vice Chancellor for research of Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
14 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion criteria: the maximum time interval between consumption and arrive patient to hospital of 1-2 hours; acute acetaminophen poisoning; consumption more than 7.5 gram of acetaminophen; drugs containing acetaminophen without affecting liver function (adult cold); age of more than14 years. Exclusion criteria: chronic acetaminophen poisoning; history of liver disease; history of Coagulopathy; coingestion; taking acetaminophen containing compounds with effects on liver function(eg.,acetaminophen codeine).
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prothrombine time. Timepoint: Befor intervention, 8 hours after intervention, 16 hours after intervention. Method of measurement: Second, blood sample.;Bleeding time. Timepoint: Befor intervention, 8 hours after intervention, 16 hours after intervention. Method of measurement: Minute. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Babak Mostafazadeh
Shahid Beheshti University of Medical Sciences
Outcome results
None listed