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Diclofenac vs. Pethidine in cholecystectomy pain

Comparison of the Effect of Diclofenac and Pethidine on the severity of the Postoperative Pain of Laparoscopic Cholecystectomy in Opiate-Dependent and Non-Dependent Patients.

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20140611018063N6
Enrollment
120
Registered
2019-09-03
Start date
2015-11-01
Completion date
Unknown
Last updated
2019-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: pain. Condition 2: Cholelithiasis. Condition 3: Acute cholecystitis. Acute pain Cholelithiasis Acute cholecystitis

Interventions

Intervention 1: Intervention group: One subset of opioid-dependent patients will be given 100 mg Diclofenac suppository through the rectal starting from 1 hour after the recovery and repeated every 6
. Intervention 2: Intervention group: One subset of opioid-independent patients will be given 100 mg Diclofenac suppository through the rectal starting from 1 hour after the recovery and repeated ever
. Intervention 3: Intervention group: one subset of opioid-dependent patients will be given 25 mg pethidine injection intravenously starting from 1 hour after the recovery and repeated every 6 hours u
. Intervention 4: Intervention group: one subset of opioid-independent patients will be given 25 mg pethidine injection intravenously starting from 1 hour after the recovery and repeated every 6 hours

Sponsors

Birjand University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: patients with detected gallstones requiring surgery patients with biliary sludge requiring surgery

Exclusion criteria

Exclusion criteria: history of laparoscopic cholecystectomy severe obstructive pulmonary disease congestive heart failure (EF <20%) acute cholecystitis gangrenous empyema gallbladder intestinal fistula in the biliary tract obesity pregnancy ventriculoperitoneal shunt previous abdominal surgery appearance of serious drug side effects cirrhosis

Design outcomes

Primary

MeasureTime frame
The effect of prescribed drug on the severity of pain. Timepoint: measuring severity of the pain before intervention, measuring severity of the pain 24 hours after the initiation of the anti-pain drug (pethidine or diclofenac). Method of measurement: verbal rating scale of pain.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Rajabpour-Sanati

Birjand University of Medical Sciences

ali.poursanati@gmail.com+98 56 3234 1067

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026