The effect of probiotic capsule supplementation on severity depression

The effect of probiotic capsule supplementation on severity depression among patients with major depressive disorder under treatment with citalopram

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014060717993N1

Enrollment

Registered

2014-11-04

Start date

2014-07-01

Completion date

Unknown

Last updated

2020-11-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depression. Depressive episode

Interventions

Intervention 1: Multi species probiotic capsules containing Lactobacillus acidophilus 2× 109 CFU, Lactobacillus casei 2× 109 CFU, Bifidbacterium bifidum 2 × 109 CFU. Intervention 2: Control group:

Eligibility

Sex/Gender

All

Age

20 Years to 55 Years

Inclusion criteria

Inclusion criteria: Patients with major depressive Aged between 20 to 55 years

Exclusion criteria

Exclusion criteria: Age 55 years A history of coronary infarction Angina pectoris Pregnancy or lactation Substance abuse Taking dietary supplements or probiotic supplements during the previous 2 months

Design outcomes

Primary

Measure	Time frame
Severity depression. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Questionnaire Beck.	—

Secondary

Measure	Time frame
Insulin resistance. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Calculation using the Homeostasis Model Assessment (HOMA) formula.;Insulin. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: ELISA kit.;Fasting plasma glucose. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Enzymatic kit.;Total cholesterol. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Enzymatic kit.;Triglycerides. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Enzymatic kit.;High-density lipoprotein (HDL). Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Enzymatic kit.;Low-density lipoprotein (LDL). Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Enzymatic kit.;High-sensitivity C-reactive Protein (hs-CRP). Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: ELISA kit.;Glutathione. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Spectrophotometry.;Total antioxidant capacity. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Spectrophotometry.	—

Measure

Time frame

Insulin resistance. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Calculation using the Homeostasis Model Assessment (HOMA) formula.;Insulin. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: ELISA kit.;Fasting plasma glucose. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Enzymatic kit.;Total cholesterol. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Enzymatic kit.;Triglycerides. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Enzymatic kit.;High-density lipoprotein (HDL). Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Enzymatic kit.;Low-density lipoprotein (LDL). Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Enzymatic kit.;High-sensitivity C-reactive Protein (hs-CRP). Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: ELISA kit.;Glutathione. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Spectrophotometry.;Total antioxidant capacity. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Spectrophotometry.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Gholam Ali Hamidi

Research Department of Kashan University of Medical Sciences

hamiidi@yahoo.com+98 31 5554 2999

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026