Cisplatin nephrotoxicity. Acute kidney failure, unspecified
Conditions
Interventions
Intervention 1: Atorvastatin( sobhan) 40 mg,1 hour before cisplatin administration then continue atorvastatin daily till 7 days after starting cisplatin. Intervention 2: Control group: placebo starts
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: New cases of patients with solid tumors under Cisplatin therapy, minimum age of 18 glomerular filtration rate( GFR) > 60 ml/min serum creatinine less than 1.5 mg/dl
Exclusion criteria
Exclusion criteria: Patients who used cisplatin less than 50mg/m2 or divided dose of cisplatin in several days patients with a past history of Cisplatin therapy, chronic kidney disease, NSAIDS usage or using any nephrotoxic drugs will not participate in this study patients with a history of NSAIDS usage or using any nephrotoxic drugs will not participate in this study patients with a historyof chronic kidney disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of people with renal failure. Timepoint: measurement of blood Urea nitrogen, creatinine, potassium, magnesium before intervention and 8 and 21 days after intervention. Method of measurement: measurement of blood Urea nitrogen, creatinine, potassium, magnesium. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNasrin Namdari
Shiraz University of Medical Sciences
Outcome results
None listed