Methamphetamine Dependency. Mental and behavioural disorders due to use of other stimulants, including caffeine.Dependence syndrome
Conditions
Interventions
Intervention 1: Intervention group: Buprenorphine sublingual tab began at a dose of 2 mg per day and increased to 6 mg within 7 days (3 sublingual tablets) and this amount continued for 4 months. Inte
Treatment - Drugs
Placebo
Intervention group: Buprenorphine sublingual tab began at a dose of 2 mg per day and increased to 6 mg within 7 days (3 sublingual tablets) and this amount continued for 4 months.
Control group: A placebo with similar medicinal form to buprenorphine which is in sublingual form, began and continued for 4 months.
Sponsors
Isfahan University of Medical Sciences, Behavioral Sciences Research Center
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: men and women age 18–40 years old; diagnosed with methamphetamin dependency according to DSM-IV criteria; informed acceptance to comply with study procedures. Exclusion criteria: sever medical illness that would impair the ability to participate safely in the study; a current neurological or axis I psychiatric disorders not due to substance abuse (e.g., schizophrenia, dementia) that would impair ability to participate safely in the study; current pregnancy or nursing in women; current serious suicidal intention or plan; more than 3 times elevation of AST and ALT at screening; subjects who met DSM-IV criteria for opiates dependence.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Methamphetamine Craving. Timepoint: At screening and every 2 weeks up to 4 months. Method of measurement: Cocaine Craving Questionnaire-Brief (CCQ-Brief). | — |
Secondary
| Measure | Time frame |
|---|---|
| Vomiting. Timepoint: At screening and every 2 weeks up to 4 months. Method of measurement: History and Physical examination.;Dyspepsia. Timepoint: At screening and every 2 weeks up to 4 months. Method of measurement: History and Physical examination.;Drowsiness. Timepoint: At screening and every 2 weeks up to 4 months. Method of measurement: History and Physical examination. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAli Reza Emadossadati
Isfahan University of Medical Sciences, Department of Psychiatry
Outcome results
None listed