Gastric adenocarcinoma. Malignant neoplasm of stomach
Conditions
Interventions
Intervention 1: Control group:
Surgical exploration without neoadjuvant chemotherapy. Intervention 2: Intervention Group
Neoadjuvant chemotherapy:
- docetaxel 75 mg/m2, IV, 1 hour infusion, day 1
-
Treatment - Surgery
Treatment - Drugs
Control group:
Surgical exploration without neoadjuvant chemotherapy
Intervention Group
Neoadjuvant chemotherapy:
- docetaxel 75 mg/m2, IV, 1 hour infusion, day 1
- cisplatin 75 mg/m2, IV , 2hour infusion, day 1
- 5 FU 750 mg/m2/day, IV continuous infusion, days
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1) Age between 18-70 years old 2) Confirmation of gastric adenocarcinoma by endoscopic sampling and histopathological analysis 3) Confirmation of locally-advanced disease by preoperative computed tomography 4) Confirmation of resectability by preoperative computed tomography Exclusion criteria: 1) Ages older than 70 2) Gastric malignancies other than adenocarcinoma 3) Distant metastasis in preoperative assessment 4) Any contraindication to chemotherapy 5) History of previous chemotherapy 6) History of previous radiotherapy
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reseactability. Timepoint: Intraoperative (After chemotherapy in case group and after diagnosis in control group). Method of measurement: Intraoperative findings. | — |
Secondary
| Measure | Time frame |
|---|---|
| Local lymph node regression. Timepoint: After neoadjuvant chemotherapy (6 weeks). Method of measurement: Computed tomography. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Shahriyar Hashemzadeh
Tabriz University of Medical Sciences
Outcome results
None listed