To investigate anti-inflammatory and anti oxidative stress effects of Curcumin on sulfur mustard-induced lung complications in Iranian veterans

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014052817888N1

Enrollment

Registered

2015-02-23

Start date

2012-08-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung complications of Sulfur Mustard. ????? ?????? ??? ??????? ?? ????? ??? ??????

Interventions

Intervention 1: Patients: Curcumin will be administrated for the patients(N=20) in the form of C3 Complex capsules (500mg) twice a day, 1 capsule each 12 hours. Intervention 2: Controls:Placebo capsul

Treatment - Drugs

Patients: Curcumin will be administrated for the patients(N=20) in the form of C3 Complex capsules (500mg) twice a day, 1 capsule each 12 hours.

Controls:Placebo capsules will be used for the control group (N=20) containes piperine5 mg (500mg) , twice a day, 1 capsule each 12 hours. Placebo capsules are mached in shape and size with curcumin c

Eligibility

Sex/Gender

Male

Age

25 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Chemical injuries resulting from mustard gas with pulmonary complications, according to medical records at three levels of severity (mild, moderate, severe) according to PFTs results Exclusion criteria: History of allergy to herbal medicine; The need for hospitalization due to the severity of the disease; Taking any antioxidant supplements (vitamin C, E or selenium) at least two weeks before participating in the project ; Contact with a chemical gas in a business environment; smoking .

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
FEV1. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: spirometery test.;FVC. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: spirometery test.;FEV1/FVC. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: spirometery test.;IL-4. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis.;IL-8. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis.;IL-13. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis.;TNF-a. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis.;MCP-1. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis.;LDL. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis.;HDL. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis.;Total Cholestrol. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis.;TG. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis.;Lp[a]. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis.;SOD. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis.;MDA. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis.;CAT. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis.;IgE. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis.;IgG. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis.;H-Cys. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis.;Weight. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Kg.	—

Measure

Time frame

FEV1. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: spirometery test.;FVC. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: spirometery test.;FEV1/FVC. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: spirometery test.;IL-4. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis.;IL-8. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis.;IL-13. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis.;TNF-a. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis.;MCP-1. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis.;LDL. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis.;HDL. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis.;Total Cholestrol. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis.;TG. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis.;Lp[a]. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis.;SOD. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis.;MDA. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis.;CAT. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis.;IgE. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis.;IgG. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis.;H-Cys. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis.;Weight. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Kg.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactZahra Khabjavid

Mashhad University Of Medical Sciences ,Faculty Of Medicin, Department Of Biochemistry

khabjavid@yahoo.com+98 912 867 5267

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026