Major depressive disorder. Major Depressive episode
Conditions
Interventions
Intervention 1: CapsuleMinocycline100 mg BID as intervention group for 6 weeks. Intervention 2: Cap. placebo as control group for 6 weeks.
Treatment - Drugs
Placebo
CapsuleMinocycline100 mg BID as intervention group for 6 weeks
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1-Confirmation of HIV infection by Western-blot test 2-receiving HAART medications 3- score lower than 20 in Hamilton Rating Scale for depression 4-Mild to moderate major depressive disorder based on DSM-V 5-consent for entering the trial Exclusin criteria: 1-receving antidepressants, 2-ongoing addiction, 3-opportunistic infections during 45 days before entering the trial, 4-severe depression and suicidality, 6-death of loved ones during the last month, 7-active infection and fever, 8-cancer, 9-pregnancy, 10-alcohol dependence, 11-history of allergy to minocycline or other tetracyclines, 12- Cognitive disorders including dementia due to HIV
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of depression. Timepoint: Baseline and weeks 1-3-6 after beginig of treatment. Method of measurement: by Hamiltion Depression Rating Scale 17-Item. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactProf. Shahin Akhondzadeh
Tehran University of Medical Sciences
Outcome results
None listed