assessment of immune system during Low Calorie Diet induced weight loss

Comparison of changes in lymphocyte subpopulations during weight loss program on obese subjects and control group

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014052617872N1

Enrollment

Registered

2014-10-30

Start date

2015-03-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity. Simple obesity NOS

Interventions

Intervention 1: Low Calorie Diet by 500 Kcal less than reqirement up to 10-15% weight loss. Intervention 2: administration of orlistat(120mg) twice a day with lunch and dinner. Intervention 3: 1 hour

Treatment - Other

Treatment - Drugs

Lifestyle

Low Calorie Diet by 500 Kcal less than reqirement up to 10-15% weight loss

administration of orlistat(120mg) twice a day with lunch and dinner

1 hour moderate physical activity(VO2 max 60%)

Administration of 15gr soluble fiber twice a day before lunch and dinner

Eligibility

Sex/Gender

Female

Age

25 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Female; Age 25-40years; BMI = 30.00; Normal thyroid function; Normal blood cortisol; Normal mensturation; Healthy individuals(without any certain diseases); Normal HbA1c; Normal blood glucose test; Non smokers; non alcohol consumption Exclusion criteria:Any drug consumption; Anemic Individuals

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
T Lymphocyte CD4+. Timepoint: Befor and after the intervention (Day 0 of intervention and after 10-15% weight loss). Method of measurement: flow cytometry.;T Lymphocyte CD3+. Timepoint: Befor and after the intervention (Day 0 of intervention and after 10-15% weight loss). Method of measurement: flow cytometry.;B Lymphocyte CD19+. Timepoint: Befor and after the intervention (Day 0 of intervention and after 10-15% weight loss). Method of measurement: flow cytometry.;Natural Killer Cells CD16/56+. Timepoint: Befor and after the intervention (Day 0 of intervention and after 10-15% weight loss). Method of measurement: flow cytometry.;T Lymphocyte CD8+. Timepoint: Befor and after the intervention (Day 0 of intervention and after 10-15% weight loss). Method of measurement: flow cytometry.	—

Measure

Time frame

T Lymphocyte CD4+. Timepoint: Befor and after the intervention (Day 0 of intervention and after 10-15% weight loss). Method of measurement: flow cytometry.;T Lymphocyte CD3+. Timepoint: Befor and after the intervention (Day 0 of intervention and after 10-15% weight loss). Method of measurement: flow cytometry.;B Lymphocyte CD19+. Timepoint: Befor and after the intervention (Day 0 of intervention and after 10-15% weight loss). Method of measurement: flow cytometry.;Natural Killer Cells CD16/56+. Timepoint: Befor and after the intervention (Day 0 of intervention and after 10-15% weight loss). Method of measurement: flow cytometry.;T Lymphocyte CD8+. Timepoint: Befor and after the intervention (Day 0 of intervention and after 10-15% weight loss). Method of measurement: flow cytometry.

—

Secondary

Measure	Time frame
Zinc. Timepoint: Befor and after the intervention (Day 0 of intervention and after 10-15% weight loss). Method of measurement: Blood test.;Iron. Timepoint: Befor and after the intervention (Day 0 of intervention and after 10-15% weight loss). Method of measurement: Blood test.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahsa Mehrdad

Mashhad University of Medical Scienses

Mehrdad@sums.ac.ir+98 918 380 9662

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026