Comparison of the Efficacy of Low-Dose Ketamine, and Morphine in pain managment

Comparison of the Efficacy of Low-Dose Intranasal Ketamine, Subcutaneous Ketamine, and Morphine in Pain Management of Acute Musculoskeletal Pain in Traumatic Patients Presenting to the Emergency Department

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20140524017812N5

Enrollment

126

Registered

2026-05-27

Start date

2026-05-31

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain of musculoskeletal trauma. Acute pain due to trauma

Interventions

Intervention 1: Intervention group: intranasal ketamine. Intervention 2: Intervention group: subcoutaneous ketamine.

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Acute Musculoskeletal Trauma severity of pain > 5

Exclusion criteria

Exclusion criteria: allergy to ketamine or morphine loss of consciousness Pregnancy or breastfeeding uncontrolled hypertension, unstable ischemic heart disease, heart failure, renal failure (Cr >1.5), liver cirrhosis History of psychosis or current use of antipsychotic medications Use of narcotics, sedatives, or muscle relaxants in the past 24 hours Facial or nasal injury that prevents nasal administration

Design outcomes

Primary

Measure	Time frame
Pain reduction. Timepoint: 0-15-30-60 minute. Method of measurement: numeric scale rating 0-10.	—

Secondary

Measure	Time frame
Side effects Such as apnea, agitation, nausea and vomiting. Timepoint: 0-15-30-60 min. Method of measurement: Qualitative and patient expression or researcher observation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactGholamreza Faridaalaee

Tabriz University of Medical Sciences

faridaalaee@tbzmed.ac.ir+98 41 3382 9540

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026