Treatment of chronic and resistant conventional therapy constipation .

A comparative study of the effects of pyridostigmine and bisacodyl in Refractory constipation.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201405227080N2

Enrollment

Registered

2014-12-05

Start date

2012-06-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Constipation. Other diseases of the digestive system

Interventions

Intervention 1: Intervention group1: 4 weeks use of pyridostigmine( 60mg, Every 8 hours ). Intervention 2: Intervention group 2: 4 weeks use of bisacodyl (5mg, Every 8 hours ).

Treatment - Drugs

Intervention group1: 4 weeks use of pyridostigmine( 60mg, Every 8 hours )

Intervention group 2: 4 weeks use of bisacodyl (5mg, Every 8 hours )

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients who have constipation for more than a year and have not responded to conventional treatments . Exclusion criteria: age below 18 and above 75, the underlying disease affecting gastrointestinal motility (eg, hypothyroidism, diabetes and neurological diseases), the use of drugs affecting gastrointestinal motility (eg calcium channel blockers), history of abdominal surgery

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
The shape of stool. Timepoint: At the start of the intervention, Two weeks later, Four weeks later. Method of measurement: Based on image measurement.;The number of stools per week. Timepoint: At the start of the intervention, Two weeks later, Four weeks later. Method of measurement: Questionnaire.;Feeling of incomplete defecation. Timepoint: At the start of the intervention, Two weeks later, Four weeks later. Method of measurement: Questionnaire.;Duration of Defecation per time. Timepoint: At the start of the intervention, Two weeks later, Four weeks later. Method of measurement: Questionnaire.	—

Measure

Time frame

The shape of stool. Timepoint: At the start of the intervention, Two weeks later, Four weeks later. Method of measurement: Based on image measurement.;The number of stools per week. Timepoint: At the start of the intervention, Two weeks later, Four weeks later. Method of measurement: Questionnaire.;Feeling of incomplete defecation. Timepoint: At the start of the intervention, Two weeks later, Four weeks later. Method of measurement: Questionnaire.;Duration of Defecation per time. Timepoint: At the start of the intervention, Two weeks later, Four weeks later. Method of measurement: Questionnaire.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Javad Shokri Shirvani

Babol University of Medical Sciences

javadshokri@gmail.com+98 11 3223 8284

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026