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Lorazepam effect on reducing nausea and vomiting

Comparison between effects of oral Lorazepam with placebo in decreasing nausea and vomiting after laparoscopic cholecystectomy under general anesthesia

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT2014051917742N2
Enrollment
76
Registered
2016-06-12
Start date
2015-12-22
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hyperemesis gravidarum. Hyperemesis gravidarum with metabolic disturbance

Interventions

Intervention 1: Administration of lorazepam 1 mg 60 minutes before surgery in treatment group. Intervention 2: Administration of placebo tab 60 minutes before surgery in control group.
Prevention
Administration of lorazepam 1 mg 60 minutes before surgery in treatment group
Administration of placebo tab 60 minutes before surgery in control group

Sponsors

Vice chancellor for research Ahvaz Jundishapur University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria :Age: 20-60 years, B MI<30, Duration of surgery <1 hour, ASA: I- II Exclusion criteria: Hemodynamic effect after administration of lorazepam, Anti emetic medication before surgery , Systolic blood pressure less than 90 mmHg or greater than 160 mmHg, History of drug abuse and tricyclic antidepressants

Exclusion criteria

Exclusion criteria:

Design outcomes

Secondary

MeasureTime frame
Satisfaction. Timepoint: 0,6,24 hours after surgery. Method of measurement: Likert scale.

Primary

MeasureTime frame
Nausea. Timepoint: 0,6,24 hiurs after surgery. Method of measurement: visual analog scale.;Vomiting. Timepoint: 0,6,24 hiurs after surgery. Method of measurement: visual analog scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Fatemeh Javaherforoosh Zadeh

Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

f_javaherforoosh@yahoo.com+98 61 3333 3050

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026