Impact of ketorolac and peptidine on the control of acute pain and post-operative complications of hemorroidectomy

A clinical trial comparing the effect of pethidine and ketorolac on the control of acute pain and postoperative complications of hemorrhoidectomy in patients with hemorrhoids

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20140519017756N44

Enrollment

Registered

2018-08-21

Start date

2018-05-29

Completion date

Unknown

Last updated

2018-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hemorrhoid. Unspecified hemorrhoids

Interventions

Intervention 1: Intervention Group 1 (pethidine): The group will have 0.5 mg / kg of pethidine intravenously immediately after the end of operation, and then takes this drug at a dose of 50 mg 3 times

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with hemorrhoids in ASA class I and class II Age older than 18 years Informed consent for participation

Exclusion criteria

Exclusion criteria: Regular or substantial use of opiate, sedative, and tranquilizing drugs History of pulmonary, hepatic, renal problemsHistory of abdominal surgery Drug addiction and smoking History of allergy to non-steroidal anti-inflammatory drugs Brucellosis asthma, pregnancy, preeclampsia, and coagulation disorders

Design outcomes

Primary

Measure	Time frame
Pain severity. Timepoint: 0, 6, 12, and 24 hours after operation. Method of measurement: Visual Analogue Scale.;Nausea. Timepoint: 0, 6, 12, and 24 hours after operation. Method of measurement: Inquiry from the patient.;Vomiting. Timepoint: 0, 6, 12, and 24 hours after operation. Method of measurement: Inquiry from the patient.;Active post-operative bleeding. Timepoint: 0, 6, 12, and 24 hours after operation. Method of measurement: Inquiry from the patient.;Patient satisfaction. Timepoint: 24 hours after operation. Method of measurement: inquiry from the patient.	—

Measure

Time frame

Pain severity. Timepoint: 0, 6, 12, and 24 hours after operation. Method of measurement: Visual Analogue Scale.;Nausea. Timepoint: 0, 6, 12, and 24 hours after operation. Method of measurement: Inquiry from the patient.;Vomiting. Timepoint: 0, 6, 12, and 24 hours after operation. Method of measurement: Inquiry from the patient.;Active post-operative bleeding. Timepoint: 0, 6, 12, and 24 hours after operation. Method of measurement: Inquiry from the patient.;Patient satisfaction. Timepoint: 24 hours after operation. Method of measurement: inquiry from the patient.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDavood Asadian Ghahfarokhi

Birjand University of Medical Sciences

asadian.davood@gmail.com+98 56 3239 5600

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026