Effect of grape seed extract 5% ointment on appendectomy wound healing

Clinical trial comparing topical effects of grape seed 5% extract ointment, placebo, and no intervention on appendectomy wound healing

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT20140519017756N38

Enrollment

Registered

2018-02-19

Start date

2018-01-21

Completion date

Unknown

Last updated

2018-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

appendectomy wound healing. Other diseases of appendix

Interventions

Intervention 1: Intervention group 1 (grape seed ointment): Grape seed 5% extract ointment will be applied in 1 centimeter width and one millimeter thickness onto the sutured region using sterilized,

Eligibility

Sex/Gender

All

Age

10 Years to 30 Years

Inclusion criteria

Inclusion criteria: Age between 10 and 30 years Patient having undergone appendectomy Body mass index between 18.5 and 25 McBurney’s incision with maximum length of 10 centimeters

Exclusion criteria

Exclusion criteria: Appendicitis accompanied by perforation and gangrene Unwillingness to participate in the study or discontinued cooperation Sensitivity to grape seed ointment and the inability to follow-up the patient Peritonitis Suffering from immune system threatening diseases such as diabetes mellitus, uremia, cancer, malnutrition, hypertension and heart disease Use of immunosuppressive drugs

Design outcomes

Primary

Measure	Time frame
Appendectomy wound healing. Timepoint: second postoperative day (i.e., before intervention), eighth postoperative day (six days after intervention), and 16th postoperative day (14 days after intervention). Method of measurement: REEDA (Redness, Edema, Ecchymosis, Discharge, Approximation) scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHosain Abbasi

Birjand University of Medical Sciences

abbasi.hosain@gmail.com+98 56 3239 5001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026