Effect of Helicobacter pylori eradication on functional dyspepsia

A clinical trial comparing of the effect of Helicobacter pylori eradication and its non-eradication on functional dyspepsia in patients referring to the Gastroenterology Clinic of Birjand in 2015 and 2016

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20140519017756N37

Enrollment

117

Registered

2018-02-06

Start date

2016-03-13

Completion date

Unknown

Last updated

2018-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

functional dyspepsia. Functional dyspepsia

Interventions

Intervention 1: ntervention Group (quadruple therapy): For two weeks, the cases received clarithromycin 500 mg twice daily, amoxicillin 1 gram twice daily, and bismuth 262 mg twice daily. They also re

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with functional dyspepsia who present abdominal perineal, heartburn, nausea, vomiting, or upper abdominal pain, and some patients with early fullness absence of organ diseases such as gastroesophagitis, ulcer, and gastric and endometrial cancers according to endoscopy no history of gastric surgery no history of eradicating Helicobacter pylori positive results for Helicobacter pylori infection according to endoscopy

Exclusion criteria

Exclusion criteria: Patients who fail to complete treatment Intolerance for anti-Helicobacter pylori antibiotics Withdrawal from the study for any reason

Design outcomes

Primary

Measure	Time frame
Eradication of Helicobacter pylori. Timepoint: At the end of the intervention. Method of measurement: Urease breathing test.;Response to treatment. Timepoint: Before and after intevention. Method of measurement: Endoscopy.	—

Secondary

Measure	Time frame
Diarrhea. Timepoint: After intervention is finished. Method of measurement: Questioning the patient.;Skin rash. Timepoint: After intervention is finished. Method of measurement: Physical examination and questioning the patient.;Severe headache. Timepoint: After intervention is finished. Method of measurement: Physical examination and questioning the patient.;Dry mouth. Timepoint: After intervention is finished. Method of measurement: Physical examination and questioning the patient.;Nausea and vomiting. Timepoint: After intervention is finished. Method of measurement: Physical examination and questioning the patient.;Bitter mouth. Timepoint: After intervention is finished. Method of measurement: Physical examination and questioning the patient.;Stomachache. Timepoint: After intervention is finished. Method of measurement: Physical examination and questioning the patient.	—

Measure

Time frame

Diarrhea. Timepoint: After intervention is finished. Method of measurement: Questioning the patient.;Skin rash. Timepoint: After intervention is finished. Method of measurement: Physical examination and questioning the patient.;Severe headache. Timepoint: After intervention is finished. Method of measurement: Physical examination and questioning the patient.;Dry mouth. Timepoint: After intervention is finished. Method of measurement: Physical examination and questioning the patient.;Nausea and vomiting. Timepoint: After intervention is finished. Method of measurement: Physical examination and questioning the patient.;Bitter mouth. Timepoint: After intervention is finished. Method of measurement: Physical examination and questioning the patient.;Stomachache. Timepoint: After intervention is finished. Method of measurement: Physical examination and questioning the patient.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarzaneh Dashti

Birjand University of Medical Sciences

naz.parisa@yahoo.com+98 56 3244 6895

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026