The effects of three anesthetics on the amount of intraoperative bleeding

Comparing the effects of clonidine, morphine and promethazine as pre-medication on intraoperative bleeding and hemodynamic stability of patients during septorhinoplasty surgeries

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20140519017756N36

Enrollment

Registered

2018-01-31

Start date

2017-06-08

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

intraoperative bleeding. Deviated nasal septum

Interventions

Intervention 1: Intervention group (morphine): Receiving 0.1 milligram/kilogram body weight of morphine intramuscularly an hour before surgery. Intervention 2: Intervention group (Promethazine): 25 mi

Treatment - Drugs

Intervention group (morphine): Receiving 0.1 milligram/kilogram body weight of morphine intramuscularly an hour before surgery

Intervention group (Promethazine): 25 milligrams of promethazine (syrup or tablet) an hour before surgery

Intervention group (clonidine): 300 micrograms of clonidine tablets an hour before surgery

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: aged between 18 and 60 years; no history of cardiac, pulmonary or renal diseases; no bleeding disorders such as hemophilia, thalassemia and leukemia; no severe psychosomatic disorder; no treatment with tricyclic anti-depressant drugs, monoamine oxidase enzyme inhibitors, or anti-coagulant drugs.

Exclusion criteria

Exclusion criteria: having systolic blood pressure above 160 mmHg and diastolic blood pressure above 90 mmHg; heart rate less than 50 per minute; unwillingness to collaborate in the study.

Design outcomes

Primary

Measure	Time frame
Systolic and diastolic blood pressure. Timepoint: Before induction of anesthesia, after intubation of the patient, and every 30 minutes after the start of operation. Method of measurement: Using Monitoring Device made by Saadat Company.;Mean arterial pressure. Timepoint: Before induction of anesthesia, after intubation of the patient, and every 30 minutes after the start of operation. Method of measurement: Using Monitoring Device made by Saadat Company.;Pulse. Timepoint: Before induction of anesthesia, after intubation of the patient, and every 30 minutes after the start of operation. Method of measurement: Using Monitoring Device made by Saadat Company.;Saturation of red blood cells. Timepoint: Before induction of anesthesia, after intubation of the patient, and every 30 minutes after the start of operation. Method of measurement: Using Monitoring Device made by Saadat Company.;The amount of bleeding. Timepoint: completion of surgery. Method of measurement: Weighing the used blood-soaked gauzes and calculating the amount of blood in the suction.	—

Measure

Time frame

Systolic and diastolic blood pressure. Timepoint: Before induction of anesthesia, after intubation of the patient, and every 30 minutes after the start of operation. Method of measurement: Using Monitoring Device made by Saadat Company.;Mean arterial pressure. Timepoint: Before induction of anesthesia, after intubation of the patient, and every 30 minutes after the start of operation. Method of measurement: Using Monitoring Device made by Saadat Company.;Pulse. Timepoint: Before induction of anesthesia, after intubation of the patient, and every 30 minutes after the start of operation. Method of measurement: Using Monitoring Device made by Saadat Company.;Saturation of red blood cells. Timepoint: Before induction of anesthesia, after intubation of the patient, and every 30 minutes after the start of operation. Method of measurement: Using Monitoring Device made by Saadat Company.;The amount of bleeding. Timepoint: completion of surgery. Method of measurement: Weighing the used blood-soaked gauzes and calculating the amount of blood in the suction.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Rahmanifar

Birjand University of Medical Sciences

Dr.m.rahmanifar@gmail.com+98 56 3239 5000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026