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The effect of adding nitroglycerin to morphine in intravenous pain control pumps

Comparison of analgesic and hemodynamic effects of morphine sulphate alone and morphine sulphate plus nitroglycerine in candidates for simple abdominal surgeries using intravenous patient-controlled analgesia

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20140519017756N33
Enrollment
60
Registered
2018-01-27
Start date
2016-12-21
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-operative pain. Other chronic postprocedural pain

Interventions

Intervention 1: Intervention group: (Morphine + Nitroglycerin): Intravenous pain pump of the case group will be filled with 0.5 milligram/kilogram morphine + 3 microgram/minute nitroglycerin. Interven
Prevention
Intervention group: (Morphine + Nitroglycerin): Intravenous pain pump of the case group will be filled with 0.5 milligram/kilogram morphine + 3 microgram/minute nitroglycerin.
Control group: (morphine): Intravenous pain pump in the control group will be filled with 0.75 milligram/kilogram morphine .

Sponsors

Birjand University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Patients with anesthesia classes 1 and 2 age from 18 to 50 years candidate for simple elective abdominal surgery (herniorrhaphy, cholecystectomy, jejunoileostomy) with surgery duration below two hours bleeding volume less than 200 cc length of incision below 10 centimeters

Exclusion criteria

Exclusion criteria: Addiction history of using any kinds of sedatives or anti-nausea/vomiting drugs contraindication and sensitiveness to nitroglycerin drugs and morphine incidence of side-effects such as hypotension, headaches, nausea/vomiting, or arrhythmia requiring treatment during the use of pumps cases of turning surgeries into complex ones

Design outcomes

Primary

MeasureTime frame
Pain. Timepoint: Immediately, 2, 6, 12 and 24 hours after operation. Method of measurement: Visual Analogue Scale.;Systolic and diastolic blood pressure. Timepoint: Immediately, 2, 6, 12 and 24 hours after operation. Method of measurement: Saadat Company Monitoring Device.

Secondary

MeasureTime frame
Nausea and vomiting. Timepoint: Immediately, 2, 6, 12 and 24 hours after operation. Method of measurement: Examination.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Azadeh Sekhavati

Birjand University of Medical Sciences

roozgar@bums.ac.ir+98 56 3222 2300

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026