Effect of dried hydro alcoholic extract of pomegranate pericarp on oxidattive and inflammation state, Metaloproteinase 1, metabolic markers and clinical sign in women with knee osteoarthritis

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201405183664N11

Enrollment

Registered

2014-10-27

Start date

2014-08-06

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

osteoarthritis.

Interventions

Intervention 1: intervention group: 500mg dried hydro alcoholic extract of pomegranate pericarp capsule twice a day. Intervention 2: control group:500 mg placebo capsule ( starch ).

Treatment - Drugs

intervention group: 500mg dried hydro alcoholic extract of pomegranate pericarp capsule twice a day

control group:500 mg placebo capsule ( starch )

Eligibility

Sex/Gender

Female

Age

38 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: females aged 38-60 years-old? Primary bilateral knee osteoarthritis with mild to moderate severity based on American College of Rheumatology criteria? Body mass index within range of 30-35 kg/m2 ? Exclusion criteria : Severe osteoarthritis( grade IV)? Secondary knee osteoarthritis based on ACR criteria? knee surgery or intra-articular injection? Neuromuscular diseases ? diabetes? cardiovascular disease? metabolic diseases? kidney and hepatic diseases? Smoking? Alcohol intake? Vitamin and Mineral,W3, W6 and other antioxidant supplement consumption one month before study and throughout the study? History of MI? History of peptic or duodenal ulcers? Allergy to pomegranate? Use of non-steroidal anti-inflammatory drugs(one week before study until the end of study)? 3035kg/m2 ?

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
MDA. Timepoint: befor and the end of study. Method of measurement: mmol/l.;TAC. Timepoint: befor and the end of study. Method of measurement: mmol/l.;GPX,SOD. Timepoint: befor and the end of study. Method of measurement: unit/hemogloboline g.;MCP1, NFkB. Timepoint: befor and the end of study. Method of measurement: pg/ml.;Hs-CRP. Timepoint: befor and the end of study. Method of measurement: mg/l.;MMP1. Timepoint: befor and the end of study. Method of measurement: pg/ml.;Lipid profile. Timepoint: befor and the end of study. Method of measurement: mg/dl.;Sistolic and diastolic BP. Timepoint: befor and the end of study. Method of measurement: mmHg.	—

Measure

Time frame

MDA. Timepoint: befor and the end of study. Method of measurement: mmol/l.;TAC. Timepoint: befor and the end of study. Method of measurement: mmol/l.;GPX,SOD. Timepoint: befor and the end of study. Method of measurement: unit/hemogloboline g.;MCP1, NFkB. Timepoint: befor and the end of study. Method of measurement: pg/ml.;Hs-CRP. Timepoint: befor and the end of study. Method of measurement: mg/l.;MMP1. Timepoint: befor and the end of study. Method of measurement: pg/ml.;Lipid profile. Timepoint: befor and the end of study. Method of measurement: mg/dl.;Sistolic and diastolic BP. Timepoint: befor and the end of study. Method of measurement: mmHg.

—

Secondary

Measure	Time frame
Physical activity. Timepoint: befor,middle and the end of study. Method of measurement: qustionarie.;BMI. Timepoint: befor and the end of study. Method of measurement: kg/m2.;Weight. Timepoint: befor and the end of study. Method of measurement: kg.;Macro and micro nutrients. Timepoint: befor,middler and the end of study. Method of measurement: questionarie.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahdiyeh Khadem Haghighian

Nutrition faculty

mah_kh1362@yahoo.com+98 41 1386 3924

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026