Effect of oral Hydroxyzine on heart rate variability

Cardiac autonomic system responses to oral administration of Hydroxyzine hydrochloride in male healthy subjects.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014051611236N5

Enrollment

Registered

2014-05-26

Start date

2014-05-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy.

Interventions

Intervention 1: Oral administration of 10 mg Hydroxyzine. Intervention 2: Oral administration of 5 mg Hydroxyzine. Intervention 3: Oral administration of placebo. Intervention 4: Oral administration o

Treatment - Drugs

Placebo

Oral administration of 10 mg Hydroxyzine

Oral administration of 5 mg Hydroxyzine

Oral administration of placebo.

Oral administration of 20 mg Hydroxyzine

Eligibility

Sex/Gender

Male

Age

19 Years to 24 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: male; ages between 19-24 years old. Exclusion criteria: chronic disease (i.e. diabetes mellitus, hypertension, epilepsy and etc); smoker; under regular medication .

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Mean of RR interval. Timepoint: before and after administration of placebo or drug. Method of measurement: Time domain analysis of ECG.	—

Secondary

Measure	Time frame
Standard deviation of RR interval. Timepoint: before and after administration of placebo or drug. Method of measurement: Time domain analysis of ECG.;High frequency power spectrum. Timepoint: before and after administration of placebo or drug. Method of measurement: Frequency domain analysis of ECG.	—

Countries

Iran (Islamic Republic of)

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026