The effect of Zataria Multiflora on protection of salivary glands from radiation damage

Assessment of Zataria Multiflora essential oil on protection of salivary glands from radiation damage in differentiated thyroid cancer patients in a randomized double-blinded, placebo controlled, clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20140514017684N8

Enrollment

Registered

2020-11-12

Start date

2020-11-15

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Salivary glands' damage.

Interventions

Intervention 1: Intervention group: Patients will receive 20 drops of 2% solution of Zataria multiflora essential oil, commercially available as Gastrolith made by Barij Essential company from 1 week

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients affected with thyroid cancer who are candidates for radio-iodine therapy

Exclusion criteria

Exclusion criteria: Patients whose ages are less than 18 Patients who are affected with diseases affecting salivary glands such as Sjogren

Design outcomes

Primary

Measure	Time frame
Ejection fraction of Parotid glands. Timepoint: Before radioactive iodine therapy and 6 months after that. Method of measurement: Salivary gland scintigraphy.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahdi Haghighatafshar

Shiraz University of Medical Sciences

afsharm@sums.ac.ir+98 71 3647 4333

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026