Intravenous Acetaminophen analgesic effects and improvement of cardiac function in myocardial infarction

The role of intravenous Acetaminophen versus intravenous Morphine sulfate in pain management and improvement of cardiac function in post acute MI patients who admitted to Hamadan Ekbatan Hospital

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201405133954N7

Enrollment

Registered

2015-04-26

Start date

2014-09-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Acute myocardial infarction. Condition 2: Analgesia. Acute myocardial infarction Incl.:myocardial infarction specified as acute or with a stated duration of 4 weeks (28 days) or less from onsetExcl.:certain current complications following acute myocardial infarction (I23.-) myocardial infarction:•old (I25. Cardiac murmurs and other cardiac sounds ? Abnormalities of heart beat ? Pain in throat and chest ? Other symptoms and signs involving the circulatory and respiratory systems

Interventions

Intervention 1: All patients will receive initial treatment of myocardial infarction in arrival emergency department.The treatment consists of oxygen by nasal, oral aspirin 325 mg, sublingual nitrate

Treatment - Drugs

In the control group if there is pain, will prescribe Morphine Sulfate 3 mg IV every 6 hours. Pain score using Visual Analogue Scale for 0.5, 1, 2, 4, 6, 12, 18 and 24 hours after MI is measured. Also

All patients will receive initial treatment of myocardial infarction in arrival emergency department.The treatment consists of oxygen by nasal, oral aspirin 325 mg, sublingual nitrate for up to 3 dos

Eligibility

Sex/Gender

All

Age

40 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 40-80 years old patients ? who admitted to Hamedan Ekbatan hospital with using signs and ECG for the detection of myocardial infarction . Exclusion criteria: systolic blood pressure less than 100 mm Hg or greater than 200 mm Hg ? diastolic blood pressure below 60 mm Hg ? history of previous myocardial infarction ? fibrinolytic therapy or revascularization ? hepatic and renal disease ? addiction to Opium consumption ? VAS(Visual Analogue Scale) greater than 3 ? loss of consciousness.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Myocardial infarction pain. Timepoint: 0,0.5,1,2,4,6,12,18,24 hours after myocardial infarction. Method of measurement: Visual Analogue Scale.;Heart rate. Timepoint: 0,0.5,1,2,4,6,12,18,24 hours after myocardial infarction. Method of measurement: Holter monitoring.;Arterial blood pressure. Timepoint: 0,0.5,1,2,4,6,12,18,24 hours after myocardial infarction. Method of measurement: Holter monitoring.	—

Measure

Time frame

Myocardial infarction pain. Timepoint: 0,0.5,1,2,4,6,12,18,24 hours after myocardial infarction. Method of measurement: Visual Analogue Scale.;Heart rate. Timepoint: 0,0.5,1,2,4,6,12,18,24 hours after myocardial infarction. Method of measurement: Holter monitoring.;Arterial blood pressure. Timepoint: 0,0.5,1,2,4,6,12,18,24 hours after myocardial infarction. Method of measurement: Holter monitoring.

—

Secondary

Measure	Time frame
Cardiac function. Timepoint: 3rd and 42th days after myocardial infarction. Method of measurement: by Echocardiograghy.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactBehzad Roozbahani MD

Hamedan university of medical science

behzadroozbahani@gmail.com+98 81 3825 1244

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026