Myocardial infarction. ST elevation (STEMI) myocardial infarction of anterior wall
Conditions
Interventions
Intervention group: 300mg of oral Allopurinol at emergency ward before primary PCI and 100mg per day for one month thereafter.
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients more than 18 years old with chest pain onset less than 12 hours and diagnosed with acute anterior ST-elevation myocardial infarction( STEMI), undergoing successful primary PCI in the Tabriz Madani Heart Center.
Exclusion criteria
Exclusion criteria: Ventricular tachycardia,ventricular fibrilation,complete heart block,copmlete LBBB(Left Bundle Branch Block), /RBBB(Right Bundle branch Block) at admission Previous MI , heart failure or previous revascularization(PCI or Coronary artery bypass graft) Severe valvular heart disease Current allopurinol users Contraindications to allopurinol use Patients who have undergone "only ballon angioplasty" due to inappropriate coronary anatomy for stenting Cardiogenic shock,heart failure with killip class 2 or higher at admission Previous stroke or stroke at admission Abnormal uric acid levels above upper limit of normal
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intra Hospital Major Adverse Cardiovascular Events(MACE). Timepoint: Hospitalization Period. Method of measurement: Number of Major adverse cardiac events including death and acute heart failure.;Ischemic stroke. Timepoint: 1, 6 and 12 months after discharge. Method of measurement: Documented past medical history.;Heart failure. Timepoint: 1, 6 and 12 months after discharge. Method of measurement: clinical evidence of Heart failure via questionaire.;Mortality. Timepoint: 1, 6 and 12 months after discharge. Method of measurement: Questionaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| ST resolution >50 %. Timepoint: Admission to emergency room, 90 minutes after primary Percutaneous Coronary Intervention(PCI). Method of measurement: Electrocardiography.;Left ventricular ejection fraction. Timepoint: Admission, before discharge, one month after discharge. Method of measurement: Echocardiography.;Left ventricle end diastolic diameter. Timepoint: Admission, before discharge, one month after discharge. Method of measurement: Echocardiography. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAhmad Separham
Tabriz University of Medical Sciences
Outcome results
None listed