Nephropathy. Nephropathy induced by other drugs, medicaments and biological substances
Conditions
Interventions
Intervention 1: Patients in the intervention group will receive a single dose of silymarin tablet (280 mg) 2 hours before administration of the contrast material. Intervention 2: Patients in the place
Prevention
Placebo
Treatment - Other
Patients in the intervention group will receive a single dose of silymarin tablet (280 mg) 2 hours before administration of the contrast material.
Patients in the placebo group will receive placebo tablet 2 hours before administration of the contrast material.
All patients will be hydrated with 0.9% sodium chloride (1 mL/kg/h) for 12 hours, started 6 hours before operation and continued to 6 hours after the procedure.
Sponsors
Isfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria: having chronic stable angina; indication of coronary angiograghy; willingness to participate. Exclusion criteria: FBS >=100; eGFR < 60 cc/1.73m2; history of diabetes or kidney disease; having myocardial infarction, unstable angina, or cardiogenic shock; tacking contrast agent during one month before study.
Exclusion criteria
Exclusion criteria:
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| -. Timepoint: -. Method of measurement: -. | — |
Primary
| Measure | Time frame |
|---|---|
| Contrast induced nephropathy. Timepoint: 48 hours after angiography. Method of measurement: Measuring serum creatinine level. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactZohreh Sedighifard
Isfahan University of Medical Sciences
Outcome results
None listed