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A Randomized, Double-Blind, split-mouth, Placebo-controlled, clinical trial of the effect of sub-gingival irrigation with ibuprofen mouthwash in treatment of periodontal Diseases

A comparative evaluation of the effect of sub-gingival irrigation with ibuprofen 2% mouthwash in treatment of periodontal diseases.

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT2014050917587N4
Enrollment
22
Registered
2014-07-07
Start date
2013-11-01
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontal disesaes. Periodontal disesaes

Interventions

Intervention 1: Ibuprofen 2% mouthwash (made from the Faculty of Pharmaceutical Sciences, Islamic Azad University, Tehran). Intervention 2: Placebo Mouthwash (Made by the Faculty of Pharmaceutical Sci
Treatment - Drugs
Ibuprofen 2% mouthwash (made from the Faculty of Pharmaceutical Sciences, Islamic Azad University, Tehran)
Placebo Mouthwash (Made by the Faculty of Pharmaceutical Sciences, Islamic Azad University of Tehran)

Sponsors

Deputy of Research Council Of Dental Branch, Islamic Azad University of Tehran
Lead Sponsor

Eligibility

Sex/Gender
All
Age
10 Years to No maximum

Inclusion criteria

Inclusion criteria: Inclusion Criteria: The patients systemically healthy were selected for the study. The subjects had with periodontal pocket depths of more than 4 mm on at least two teeth in mandibular molar area that observed on probing. Exclusion Criteria: Existing systemic disease; Hypersensitive to Ibuprofen; The use of any Antibiotic or Anti-inflammatory drugs within the 6 months preceding the beginning of the study; Cancer; Pregnant or nursing females; Smoking; Orthodontic treatments; Extensive dental restorations; Use removal denture; Mouth rinses; during the entire period of the study.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Pocket depth. Timepoint: 15 Days. Method of measurement: Periodontal pobe.;Clinical attachment level. Timepoint: 15 Days. Method of measurement: Periodontal probe.

Secondary

MeasureTime frame
Reduction of bleeding on probing. Timepoint: 3 Months. Method of measurement: Periodontal probe.;Reduction of Plaque Index. Timepoint: 3 Months. Method of measurement: Loe & Silness Index.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmirhossein Farahmand

Dental Branch, Islamic Azad University of Tehran

perio-implant@hotmail.com+98 21 2284 9604

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026