Condition 1: infertility in polycystic ovarian syndrome. Condition 2: . polycystic ovarian syndrome Female infertility associated with anovulation
Conditions
Interventions
Intervention 1: letrozole 2.5 mg oral tablets twice daily, for 5 days starting on day 3 of the menstrual cycle. Intervention 2: letrozole 2.5 mg oral tablets twice daily, plus N-acetyl cysteine 600 mg
Treatment - Drugs
letrozole 2.5 mg oral tablets twice daily, for 5 days starting on day 3 of the menstrual cycle
letrozole 2.5 mg oral tablets twice daily, plus N-acetyl cysteine 600 mg oral tablets twice daily, for 5 days starting on day 3 of the menstrual cycle
Sponsors
Qazvin University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
20 Years to 35 Years
Inclusion criteria
Inclusion criteria: inclusion criteria: infertile women with PCOS (according to ESHRE/ASRM criteria) with normal hysterosalpingographies, normal spermograms of partners, and not impaired sexual functions exclusion criteria: ovarian cyst >6 cm, history of asthma or allergy, consumption of any drugs with effects on glucose metabolism during the last 3 months before entering the trial.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ovulation rate. Timepoint: 7 days after intervention (14th day of menstrual cycle). Method of measurement: detecting at least one 18 mm follicle or larger in vaginal ultrasonography.;Pregnancy rate. Timepoint: 23 days after intervention (30th day of menstrual cycle). Method of measurement: laboratory measurement of hCG-ß level. | — |
Secondary
| Measure | Time frame |
|---|---|
| Endometrial thickness. Timepoint: 7 days after intervention (14th day of menstrual cycle). Method of measurement: measuring endometrial thickness by means of vaginal ultrasonography (millimeters). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFatemeh Mohebbi
Qazvin University of Medical Sciences
Outcome results
None listed