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Randomized, double blind, placebo controlled clinical study to evaluate of topical ibuprofen gel for the inhibition of bone loss in chronic periodontitis.

Evaluation of localized ibuprofen gel compared with placebo for inhibition of bone loss in chronic periodontitis.

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT2014050517587N1
Enrollment
22
Registered
2014-06-17
Start date
2012-10-16
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontal diseases. Periodontal diseases

Interventions

Intervention 1: The ibuprofen gel (Diomed Pharmaceutical Company- England)
which be put into the periodontal pocket using an insulin syringe . Intervention 2: The placebo gel of was prepared in the same manner but without the active drug in it
(made of faculty of Islamic Azad University of Pharmaceutical Sciences)
which be put into the periodontal pocket using an insulin syringe.
Treatment - Drugs
Placebo
The ibuprofen gel (Diomed Pharmaceutical Company- England)
which be put into the periodontal pocket using an insulin syringe .
The placebo gel of was prepared in the same manner but without the active drug in it

Sponsors

Deputy of Research Council Of Dental Branch, Islamic Azad University of Tehran
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Inclusion Criteria: Systemically healthy patients with chronic periodontitis with periodontal pockets 4 millimeters deep or more at the both sides of posterior teeth in Mandibular Jaw. Exclusion Criteria: Existing systemic disease; Pregnancy; Lactation; Smokers; Patients who had taken any kind of medication during the previous six months; No periodontal treatment the previous six months; Hypersensitive to Ibuprofen; Orthodontic treatment; Cancer and Chemotherapy; Numerous large caries; The use of any mouthwash during the study.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Pocket depth. Timepoint: 15 Days. Method of measurement: Periodontal Probe.;Bleeding on probing. Timepoint: 15. Method of measurement: Periodontal Probe.

Secondary

MeasureTime frame
Increased alveolar bone density. Timepoint: 3 months. Method of measurement: Bone densitometer machine.;Reduction of plaque index. Timepoint: 3 Months. Method of measurement: Loe & Silness Index.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmirhossein Farahmand

Dental Branch, Islamic Azad University of Tehran

perio-implant@hotmail.com+98 21 2284 9604

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026